Coexistence of preeclampsia and inherited thrombophilia in Turkish pregnant women

Authors

MEHTAP POLAT
EBRU HACER BİBEROĞLU
İSMAİL GÜLER
ÖMER KUTAY BİBEROĞLU

DOI

10.3906/sag-1502-132

Abstract

Background/aim: To examine the relationship of inherited thrombophilia and other thrombotic risk factors with preeclampsia (PE) in a population of pregnant Turkish women. Materials and methods: This was a case cross-sectional study in which 70 women with PE and 60 normal pregnant women were studied to find out the frequency of women with risk factors including inherited thrombophilia among preeclamptic cases. Results: Hemoglobin, platelet count, uric acid, vitamin B12, folic acid, copper, homocysteine, plasminogen activator inhibitor-1, fibrinogen, protein S, protein C, activated protein C resistance values show significant differences in women with PE in comparison to women with normal pregnancy. Conclusion: There may be a link between inherited thrombophilia and PE, at least in a sample of Turkish pregnant women. We also propose that the association between thrombophilia and PE is stronger than suggested previously. Furthermore, copper is selectively elevated in women with PE as an independent marker.

Keywords

Copper, homocysteine, plasminogen activator inhibitor-1, protein S, activated protein C resistance

First Page

1094

Last Page

1100

Recommended Citation

POLAT, MEHTAP; BİBEROĞLU, EBRU HACER; GÜLER, İSMAİL; and BİBEROĞLU, ÖMER KUTAY (2016) "Coexistence of preeclampsia and inherited thrombophilia in Turkish pregnant women," Turkish Journal of Medical Sciences: Vol. 46: No. 4, Article 23. https://doi.org/10.3906/sag-1502-132
Available at: https://journals.tubitak.gov.tr/medical/vol46/iss4/23