To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR). Materials and methods: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated. Results: OSI at 1 h and 24 h after reperfusion was higher in the EVAR group (P = 0.004 and P = 0.002, respectively). TAS levels were higher (P = 0.001, P = 0,029). MDA levels showed no difference (P = 0.291, P = 0.076). TOS levels were lower 24 h after reperfusion in the EVAR group (P = 0.018). Conclusion: Markers of oxidative stress were lower in the EVAR group. This may be associated with advantages of EVAR. More studies are required for a clear-cut conclusion.
DOĞAN, ORHAN VELİ; MENTEŞE, ÜMİT; DOĞAN, SÜHEYLA; USTA, SEFER; TURAN, İBRAHİM; HALİLOĞLU, ERGÜN; and KARAHAN, SÜLEYMAN CANER
"Comparison of perioperative oxidative stress in endovascular and open repair of abdominal aortic aneurysm,"
Turkish Journal of Medical Sciences: Vol. 45:
1, Article 37.
Available at: https://journals.tubitak.gov.tr/medical/vol45/iss1/37