Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. Materials and methods: A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was checked using western blotting. Results: The serum level of ROS and the expression of calpain-1 were significantly higher while the activity of SOD was significantly lower in diabetic patients with myocardial infraction compared to normal individuals. Conclusion: These findings suggest a possible link between decreased antioxidant (SOD) and increased ROS levels as well as calpain-1 expression, supporting the role of oxidative stress-regulatory factors in diabetes and myocardial infraction.
Diabetes mellitus, myocardial infraction, super oxide dismutase, reactive oxygen species, calpain-1
MUSHTAQ, SOBIA; ALI, TAHIR; ALTAF, FARHANA; ABDULLAH, MUHAMMAD; and MURTAZA, IRAM
"Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction,"
Turkish Journal of Medical Sciences: Vol. 45:
1, Article 23.
Available at: https://journals.tubitak.gov.tr/medical/vol45/iss1/23