Turkish Journal of Medical Sciences
Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type-I aortic dissection
Acute aortic dissection is a life-threatening cardiovascular emergency. Neutrophil-to-lymphocyte ratio is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. The aim of the present study was to evaluate the relationship between admission neutrophil-to-lymphocyte ratio and in-hospital mortality in acute type I aortic dissection. Materials and methods: We retrospectively evaluated 123 consecutive patients who had undergone emergent surgery for acute type I aortic dissection. Patients were divided into 2 groups as patients dying in the hospital (Group 1) and those discharged alive (Group 2). All parameters, including neutrophil-to-lymphocyte ratio, were compared between the 2 groups and predictors of mortality was estimated by using multivariate analysis. Results: A total of 104 patients (79 males, mean age: 55.2 ± 14 years) were included in the final analysis. In multivariate analyses, cross-clamp time, cardiopulmonary bypass time, intensive care unit duration, platelet count, and neutrophil-to-lymphocyte ratio were found to be independent predictors of mortality. Patients with higher neutrophil-to-lymphocyte ratios had a significantly higher mortality rate (hazard ratio: 1.05; 95% CI: 1.01–1.10; P = 0.033). Receiver operating characteristic analysis revealed that using a cut-off point of 8, neutrophil-to-lymphocyte ratio predicts mortality with a sensitivity of 70% and specificity of 53%. Conclusion: This study suggests that admission neutrophil-to-lymphocyte ratio is a potential predictive parameter for determining the in-hospital mortality of acute type I aortic dissection.
Aortic dissection, neutrophil-to-lymphocyte ratio, mortality
LAFÇI, GÖKHAN; ÇİÇEK, ÖMER FARUK; UZUN, HACI ALPER; YALÇINKAYA, ADNAN; DİKEN, ADEM İLKAY; TURAK, OSMAN; ÇAĞLI, KUMRAL; TAŞOĞLU, İRFAN; GEDİK, HİKMET SELÇUK; KORKMAZ, KEMAL; GÜNERTEM, ORHAN EREN; and ÇAĞLI, KERİM
"Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type-I aortic dissection,"
Turkish Journal of Medical Sciences: Vol. 44:
2, Article 3.
Available at: https://journals.tubitak.gov.tr/medical/vol44/iss2/3