To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-\alpha) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound. Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-\alpha treatment and patients with AS who were not regularly taking any antiinflammatory drugs. Thirty-one healthy volunteers were included as controls. Results: Left-sided varicocele was determined in 14 patients of Group 1 (44%), 10 patients of Group 2 (33%), and 7 of the controls (23%). There was a statistically significant difference only between Group 1 and controls (P = 0.009). However, right-sided varicocele was determined in 12 patients of Group 1 (38%), 2 patients of Group 2 (6%), and 2 of the controls (6%) (P = 0.01 vs. Group 2, P = 0.005 vs. controls). Conclusion: The present study shows that patients with AS who were taking anti-TNF-\alpha therapy had an increased prevalence of right-sided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.
Varicocele, ankylosing spondylitis, color Doppler ultrasound
YILMAZ, ÖMER; UGAN, YUNUS; YENER, MAHMUT; UMUL, MEHMET; KAYAN, MUSTAFA; AKTAŞ, AYKUT RECEP; ÜNLÜ, ELİF NİSA; KISACIK, BÜNYAMİN; DEĞİRMENCİ, BUMİN; and ÇETİN, MELTEM
"Anti TNF-\alpha therapy might be responsible for an increased incidence of varicocele in patients with ankylosing spondylitis,"
Turkish Journal of Medical Sciences: Vol. 44:
2, Article 24.
Available at: https://journals.tubitak.gov.tr/medical/vol44/iss2/24