Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds

Authors

WAQAR AHMAD KALEEM
MUHAMMAD NISAR
Mughal QAYUM
MUHAMMAD ZIA-UL-HAQ
MUHAMMAD IQBAL CHOUDHARY
SEZAİ ERCİŞLİ

Abstract

To determine the urease inhibitory potential of extracts and isolated compounds from Zizyphus oxyphylla Edgew. Materials and methods: Methanolic extracts and subsequent fractions of Z. oxyphylla stem and 3 isolated compounds from the roots of Z. oxyphylla were obtained through column chromatography and subjected to in vitro urease inhibition. Results: Three fractions (n-hexane, ethyl acetate, and butanol fractions) showed good to excellent activity, while the chloroform fraction showed nonsignificant activity. Amongst the isolated compounds, oxyphylline D (1) was the most active of the 3 isolated cyclopeptide alkaloids, followed by nummularin R (3) and nummularin C (2). Conclusion: Z. oxyphylla has the potential to be used in the treatment of various complications produced by urease enzymes, such as gastric ulcers.

DOI

10.3906/sag-1208-28

Keywords

Zizyphus oxyphylla, cyclopeptide alkaloids, urease

First Page

497

Last Page

500

Recommended Citation

KALEEM, WAQAR AHMAD; NISAR, MUHAMMAD; QAYUM, Mughal; ZIA-UL-HAQ, MUHAMMAD; CHOUDHARY, MUHAMMAD IQBAL; and ERCİŞLİ, SEZAİ (2013) "Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds," Turkish Journal of Medical Sciences: Vol. 43: No. 4, Article 1. https://doi.org/10.3906/sag-1208-28
Available at: https://journals.tubitak.gov.tr/medical/vol43/iss4/1