Turkish Journal of Medical Sciences
Abstract
To determine the urease inhibitory potential of extracts and isolated compounds from Zizyphus oxyphylla Edgew. Materials and methods: Methanolic extracts and subsequent fractions of Z. oxyphylla stem and 3 isolated compounds from the roots of Z. oxyphylla were obtained through column chromatography and subjected to in vitro urease inhibition. Results: Three fractions (n-hexane, ethyl acetate, and butanol fractions) showed good to excellent activity, while the chloroform fraction showed nonsignificant activity. Amongst the isolated compounds, oxyphylline D (1) was the most active of the 3 isolated cyclopeptide alkaloids, followed by nummularin R (3) and nummularin C (2). Conclusion: Z. oxyphylla has the potential to be used in the treatment of various complications produced by urease enzymes, such as gastric ulcers.
DOI
10.3906/sag-1208-28
Keywords
Zizyphus oxyphylla, cyclopeptide alkaloids, urease
First Page
497
Last Page
500
Recommended Citation
KALEEM, WAQAR AHMAD; NISAR, MUHAMMAD; QAYUM, Mughal; ZIA-UL-HAQ, MUHAMMAD; CHOUDHARY, MUHAMMAD IQBAL; and ERCİŞLİ, SEZAİ
(2013)
"Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds,"
Turkish Journal of Medical Sciences: Vol. 43:
No.
4, Article 1.
https://doi.org/10.3906/sag-1208-28
Available at:
https://journals.tubitak.gov.tr/medical/vol43/iss4/1