Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis

Authors

CEMİLE DAYANGAN SAYAN
MÜZEYYEN GÜLNUR ÖZAKŞİT
ESMA SARIKAYA
ÖZLEM GÜN ERYILMAZ
LEYLA MOLLAMAHMUTOĞLU
RÜYA DEVEER

DOI

10.3906/sag-1205-85

Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

Keywords

Endometriosis, interleukin-8, CA-125, neutrophil-to-lymphocyte ratio

First Page

417

Last Page

423

Recommended Citation

SAYAN, CEMİLE DAYANGAN; ÖZAKŞİT, MÜZEYYEN GÜLNUR; SARIKAYA, ESMA; ERYILMAZ, ÖZLEM GÜN; MOLLAMAHMUTOĞLU, LEYLA; and DEVEER, RÜYA (2013) "Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis," Turkish Journal of Medical Sciences: Vol. 43: No. 3, Article 12. https://doi.org/10.3906/sag-1205-85
Available at: https://journals.tubitak.gov.tr/medical/vol43/iss3/12