The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats

Authors

ERGÜN UÇMAKLI
FERAH ARMUTCU
ALAATTİN ÖZTÜRK

DOI

10.3906/sag-1206-58

Abstract

To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group had increased iNOS expression and NO levels in liver tissue compared to controls. Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.

Keywords

Formaldehyde, nitric oxide, iNOS, rat liver

First Page

52

Last Page

56

Recommended Citation

UÇMAKLI, ERGÜN; ARMUTCU, FERAH; and ÖZTÜRK, ALAATTİN (2013) "The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats," Turkish Journal of Medical Sciences: Vol. 43: No. 1, Article 10. https://doi.org/10.3906/sag-1206-58
Available at: https://journals.tubitak.gov.tr/medical/vol43/iss1/10