To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group had increased iNOS expression and NO levels in liver tissue compared to controls. Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.
Formaldehyde, nitric oxide, iNOS, rat liver
UÇMAKLI, ERGÜN; ARMUTCU, FERAH; and ÖZTÜRK, ALAATTİN
"The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats,"
Turkish Journal of Medical Sciences: Vol. 43:
1, Article 10.
Available at: https://journals.tubitak.gov.tr/medical/vol43/iss1/10