To explore the causative mechanism of gastric carcinoma and to investigate the roles of circulating IGF-I and IGFBP-3 in gastric cancer. Materials and methods: Serum IGF-I and IGFBP-3 concentrations were measured using a 2-site coated tube immunoradiometric assay. Results: Serum IGF-I and IGFBP-3 values in gastric cancer patients were significantly lower compared to those in the control group. The difference between serum IGF-I/IGFBP-3 in patients and the control group was not significant. Conclusion: The low serum IGF-I and IGFBP-3 levels detected in patients with gastric cancer could be due to decreased synthesis or increased catabolism of IGF-I or both. It could be suggested that these parameters may be important in the development and prognosis of gastric cancer.
Insulin-like growth factors, insulin-like growth factor-1, stage, gastric cancer
ALTINKAYNAK, KONCA; BİLİCİ, MEHMET; BAKAN, NURİ; and AKÇAY, FATİH
"Circulating levels of IGF-I and IGFBP-3 in gastric cancer,"
Turkish Journal of Medical Sciences: Vol. 42:
8, Article 16.
Available at: https://journals.tubitak.gov.tr/medical/vol42/iss8/16