Postoperative nausea and vomiting (PONV) is a condition that adversely affects postoperative patient comfort. Supratentorial craniotomy patients were therefore monitored to establish the therapeutic efficiency of 2 different doses of palonosetron. Materials and methods: Patients scheduled for elective supratentorial craniotomy were randomly assigned to 3 groups: a control group (n = 30), a 0.05 mg palonosetron group (n = 30), and a 0.075 mg palonosetron group (n = 30). The drugs were given intravenously at the commencement of dura mater closure. Anesthesia maintenance was provided with 1 MAC sevoflurane in a 50% air and O_2 mixture. After the extubation, the patients were monitored for 72 h with respect to postoperative nausea and vomiting. Results: In the first 6 h, nausea was significantly lower in the 0.075 mg palonosetron group compared to the control group (P = 0.019). The incidences of nausea, retching, and vomiting at 0-72 h postoperatively were significantly lower in the 0.075 mg palonosetron group than in the 0.05 mg palonosetron or saline groups (P < 0.001). Conclusion: In supratentorial craniotomy cases, PONV was reduced more effectively in the 0.075 mg palonosetron group than in the 0.05 mg palonosetron and control groups.
Supratentorial craniotomy, postoperative nausea and vomiting, palonosetron
MADENOĞLU, HALİT; AKDEMİR, CİHAN; AKSU, RECEP; BİÇER, CİHANGİR; ÜLGEY, AYŞE; and BOYACI, ADEM
"The effect of palonosetron on postoperative nausea and vomiting in supratentorial craniotomy patients,"
Turkish Journal of Medical Sciences: Vol. 42:
7, Article 14.
Available at: https://journals.tubitak.gov.tr/medical/vol42/iss7/14