Evaluation of dose-related genotoxicity of desflurane by SCE human lymphocytes

Authors

BAHAR AYDINLI
AYŞEGÜL ÖZGÖK
ZELİHA ASLI DEMİR
SEYHAN YAĞAR
MEHMET ALİ ERGÜN
DERYA KARAER
MUSTAFA NECMİ İLHAN

DOI

10.3906/sag-1010-1222

Abstract

To evaluate dose-related genotoxicity of desflurane. In the literature, there are studies with equivocal data regarding the potential genotoxicity of inhalational anesthetics. However, it is important to know about the genotoxic safety of an anesthetic agent. Materials and methods: Two groups were enrolled into the study. The first group was maintained with a desflurane minimum alveolar concentration (MAC) of 0.5 and the second was maintained with 1 MAC of desflurane. Blood samples were obtained and studied at the baseline and after 3 h of anesthesia via sister chromatid exchange (SCE) assay. Results: In both groups, SCEs per cell were noted to increase after 3 h of anesthesia, though the increase was only significant in the 1 MAC group. Conclusion: There are limited data on the genotoxicity of desflurane. It seems that 1 MAC of desflurane has a genotoxic effect, as shown by SCE assay.

Keywords

Anesthesiology, desflurane, SCE

First Page

1037

Last Page

1041

Recommended Citation

AYDINLI, BAHAR; ÖZGÖK, AYŞEGÜL; DEMİR, ZELİHA ASLI; YAĞAR, SEYHAN; ERGÜN, MEHMET ALİ; KARAER, DERYA; and İLHAN, MUSTAFA NECMİ (2011) "Evaluation of dose-related genotoxicity of desflurane by SCE human lymphocytes," Turkish Journal of Medical Sciences: Vol. 41: No. 6, Article 13. https://doi.org/10.3906/sag-1010-1222
Available at: https://journals.tubitak.gov.tr/medical/vol41/iss6/13