Turkish Journal of Medical Sciences




To evaluate dose-related genotoxicity of desflurane. In the literature, there are studies with equivocal data regarding the potential genotoxicity of inhalational anesthetics. However, it is important to know about the genotoxic safety of an anesthetic agent. Materials and methods: Two groups were enrolled into the study. The first group was maintained with a desflurane minimum alveolar concentration (MAC) of 0.5 and the second was maintained with 1 MAC of desflurane. Blood samples were obtained and studied at the baseline and after 3 h of anesthesia via sister chromatid exchange (SCE) assay. Results: In both groups, SCEs per cell were noted to increase after 3 h of anesthesia, though the increase was only significant in the 1 MAC group. Conclusion: There are limited data on the genotoxicity of desflurane. It seems that 1 MAC of desflurane has a genotoxic effect, as shown by SCE assay.


Anesthesiology, desflurane, SCE

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