If a frozen section pathological examination is not performed in unilateral thyroid nodule surgery and the postoperative pathological diagnosis is cancer, a second operation may be required. Therefore, it was studied whether serum thyroid auto-antibody levels are useful or not in determining preoperative malignancy in patients with thyroid disorders. Materials and methods: It was investigated retrospectively whether there was a correlation between preoperative serum thyroglobulin (Tg), anti-thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase antibody (anti-TPO) levels and thyroid cancer in patients who had undergone thyroidectomy. Results: Two hundred and eighty-seven patients who had undergone thyroid surgery and whose preoperative serum levels of Tg, anti-Tg, and anti-TPO had been recorded were included in this study. Only 54 (18.8%) of the patients had a malignant diagnosis in the postoperative histopathological examination. Sixteen of the patients who had a postoperative malignant thyroid disease diagnosis (29.6%) had high serum Tg, anti-TPO, and/or anti-Tg levels. The rate of high serum Tg levels was significant in patients with a benign pathology (49.4% vs. 31.5%, P = 0.018). Conclusion: It appears that preoperative measurement of serum Tg, anti-TPO, and anti-Tg levels is not a useful method to predict malign thyroid diseases.
Thyroid cancers, anti-thyroid antibodies, thyroglobulin
YALÇIN, SAMET; ÜLGER, BURAK VELİ; PARLAK, ÖMER; UÇAR, ALİ ERKAN; SARIKAYA, SEYYİT MUHSİN; ÖZER, MEHMET; KORUKLUOĞLU, BİROL; YALÇIN, BÜLENT; and KUŞDEMİR, AHMET
"The role of preoperative serum thyroglobulin and thyroid auto-antibody levels before histopathological diagnosis of thyroid cancers,"
Turkish Journal of Medical Sciences: Vol. 41:
3, Article 16.
Available at: https://journals.tubitak.gov.tr/medical/vol41/iss3/16