Turkish Journal of Medical Sciences




Fluoride intake in high doses has toxic effects on various organs. Chronic fluorosis results in tubular degenerations, inflammation, fibrosis, parenchymatous nephritis, cloudy swellings, and dilations of convoluted tubules. In addition to these effects, fluoride causes deteriorative effects on the skeleton, teeth, and soft tissues. The goal of this study was to examine the impacts of chronic fluorosis on the liver tissues of mice. Materials and methods: One control group and 3 experimental groups, each group consisting of 4 male and 4 female mice, were formed to conduct the experiment. A stock solution including 2000 ppm fluoride was prepared by solving 4.44 g of NaF in 1 L of distilled water. Water with 10, 20, and 40 ppm fluoride was obtained by diluting the stock solution to give to the animals. Animals in the control group had free access to tap water with 0.3 ppm fluoride. Animals in experimental group 1 were orally given distilled water with 10 ppm fluoride, water with 20 ppm fluoride was orally given to the animals in experimental group 2, and the animals in experimental group 3 were orally given distilled water containing 40 ppm fluoride for 90 days. The animals were killed under light ether anesthesia to obtain specimens from the livers. Slides were prepared under the light microscope to examine histopathological anomalies and then photographs were taken. Results: Histopathological disorders were observed on the slides prepared from the liver specimens of the animals exposed to chronic fluorosis depending on doses of chemicals given to the animals. Hyperemia, local necrosis, hydropic degeneration, vacuolar degenerations, and swelling on hepatocytes around the central vein were detected. Conclusion: Depending on the doses of fluoride applied to the animals, degenerations in the tissues around the central vein increase.


Chronic fluorosis, mouse, liver, histopathology

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