Is oxidative stress an etiologic factor in idiopathic male infertility?

Authors

ERCAN YENİ
HALİL ÇİFTÇİ
MURAT SAVAŞ
AYHAN VERİT
ABDULLAH TAŞKIN

DOI

10.3906/sag-0907-6

Abstract

The total antioxidant capacity (TAC) and total peroxide (TP) levels in the blood and seminal plasma of idiopathic infertile patients were compared with those of fertile controls to determine the role of oxidative stress in the etiology of idiopathic male infertility. Material and methods: Thirty-two idiopathic infertile males and 30 healthy, married, age-matched control subjects were included in the study. TAC and TP levels were measured in the blood and seminal plasma, and sperm parameters were studied in both groups. Results: Sperm parameters were significantly impaired in the study group compared with the controls. Blood plasma TAC and TP levels in the patient group were 1.46 ± 0.62 mmol Trolox equiv./L and 8.38 ± 0.87 mmol H_2O_2/L, respectively, compared with 1.72 ± 1.70 mmol Trolox equiv./L and 8.59 ± 1.08 mmol H_2O_2/L in the control group. Seminal plasma TAC and TP levels in the patient and control groups were 13.48 ± 2.03 mmol Trolox equiv./L, 7.79 ± 0.38 mmol H_2O_2/L, 14.06 ± 2.30 mmol Trolox equiv./L, and 7.84 ± 0.51 mmol H_2O_2/L, respectively. TAC and TP levels in the blood and seminal plasma did not differ significantly between the patient group and the control group. Conclusion: These findings suggest that oxidative stress is not the cause of impaired sperm parameters in idiopathic infertile men.

Keywords

Idiopathic infertility, total antioxidant capacity, total peroxide, sperm parameters

First Page

1

Last Page

6

Recommended Citation

YENİ, ERCAN; ÇİFTÇİ, HALİL; SAVAŞ, MURAT; VERİT, AYHAN; and TAŞKIN, ABDULLAH (2010) "Is oxidative stress an etiologic factor in idiopathic male infertility?," Turkish Journal of Medical Sciences: Vol. 40: No. 1, Article 1. https://doi.org/10.3906/sag-0907-6
Available at: https://journals.tubitak.gov.tr/medical/vol40/iss1/1