Turkish Journal of Medical Sciences
A 37-year-old male patient with fever, mild respiratory distress, diffuse goiter, and hepatosplenomegaly was admitted to our hospital. Clinical and laboratory findings showed that he had recurrent respiratory tract infections-namely bronchiectasis-due to common variable immunodeficiency disease (CVID) and AA-type amyloid deposition in the thyroid gland. Although recurrent infections as a consequence of inadequate gammaglobulin (IVIG) substitution therapy are regarded as the main cause of the development of amyloidosis, amyloidosis in a patient with hypo/agammaglobulinemia is extremely rare. In this report we discuss the association of CVID and recurrent respiratory tract infections with secondary amyloidosis restricted to one organ, the thyroid gland, which is an uncommon site for amyloid deposition.
Common variable immunodeficiency, thyroid, amyloidosis
SOYSAL, DİLEK; TÜRKKAN, EBRU; KARAKUŞ, VOLKAN; TATAR, ERHAN; KABAYEĞİT, ÖZLEM YERSAL; and AVCI, ARZU
"A case of common variable immunodeficiency disease and thyroid amyloidosis,"
Turkish Journal of Medical Sciences: Vol. 39:
3, Article 19.
Available at: https://journals.tubitak.gov.tr/medical/vol39/iss3/19