A rare cause of neonatal hypocalcemia: malignant infantile osteopetrosis

Authors

HAKAN UZUN
EBRU YILMAZ KESKİN
DURSUN ALİ ŞENSES
AYHAN ERDEM
BÜNYAMİN DİKİCİ
KENAN KOCABAY

DOI

10.3906/sag-0709-20

Abstract

Malignant infantile osteopetrosis (MIOP) is a rare inherited bone disease characterized by reduced or dysregulated activity of osteoclasts, which results in generalized osteosclerosis. This leads to abnormal bone marrow cavity formation and to the clinical signs and symptoms of bone marrow failure and nerve compression. Symptoms related to early or late hypocalcemia may appear as the first presentation of MIOP in a newborn. We present a 14-day-old boy with neonatal hypocalcaemia due to MIOP.

Keywords

Malignant infantile osteopetrosis, neonatal hypocalcaemia

First Page

457

Last Page

460

Recommended Citation

UZUN, HAKAN; KESKİN, EBRU YILMAZ; ŞENSES, DURSUN ALİ; ERDEM, AYHAN; DİKİCİ, BÜNYAMİN; and KOCABAY, KENAN (2009) "A rare cause of neonatal hypocalcemia: malignant infantile osteopetrosis," Turkish Journal of Medical Sciences: Vol. 39: No. 3, Article 17. https://doi.org/10.3906/sag-0709-20
Available at: https://journals.tubitak.gov.tr/medical/vol39/iss3/17