Turkish Journal of Medical Sciences
DOI
10.3906/sag-0712-22
Abstract
Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world, causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by Nω-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA. Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME, and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution. Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa. Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA.
Keywords
Nitric oxide, stomach injury, acetylsalicylic acid, microscopy
First Page
13
Last Page
19
Recommended Citation
YAĞMURCA, MURAT; UÇAR, MUHARREM; FADILLIOĞLU, ERSİN; ERDOĞAN, HASAN; and ÖZTÜRK, FERAL
(2009)
"The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid,"
Turkish Journal of Medical Sciences: Vol. 39:
No.
1, Article 3.
https://doi.org/10.3906/sag-0712-22
Available at:
https://journals.tubitak.gov.tr/medical/vol39/iss1/3