Turkish Journal of Medical Sciences




Aim: There is a variation in drug response among individuals. In this study, we determined angiotensin-converting enzyme (ACE) insertion/deletion (I/D), beta2-adrenergic receptor (ADRB2) Arg16Gly and dopamine D1 receptor (DRD1) -48 G/A polymorphisms, which are presumed to be related to the transient hypertension induced by the mechanical stimulation of laryngoscopy and tracheal intubation/extubation. Materials and Methods: One hundred American Society of Anesthesiologists (ASA) class I patients were enrolled in this study. Heart rate and blood pressure were recorded before induction (T_0), after induction (T_1), during laryngoscopy/intubation (T_i) and 1, 2, 3, 4 and 5 min thereafter (T_{i-1}-T_{i-5}), before extubation (T_e) and 1, 2, 3, 4 and 5 min afterwards (T^{e-1}-T^{e-5}). ACE I/D, ADRB2 Arg16Gly and DRD1 -48 G/A polymorphisms were investigated by polymerase chain reaction-restriction fragment length polymorphism analyses. Data were analyzed by Repeated Measure Factorial Analysis of Variance. Results: During laryngoscopy, intubation and extubation, blood pressure, heart rate and rate pressure product (RPP) values increased, returning to baseline within five minutes. Increases at Ti were significant for all values when compared to T_o (p


Cardiovascular response, intubation, extubation, polymorphism

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