Aim: The purpose of this study was to measure serum prolidase activity and interleukin-2 and 6 (IL-2, IL-6) levels and to investigate the relationship of these parameters with bone mineral density (BMD) and bone turnover markers in postmenopausal women with and without osteoporosis. Materials and Methods: 59 postmenopausal women were included in this study (21 women with osteoporosis and 38 without). Serum IL-2 and IL-6 levels, prolidase activity, osteocalcin (OSC), calcium (Ca), alkaline phosphatase (ALP), urinary deoxypyridinoline (DPD) and BMD were measured in postmenopausal women with and without osteoporosis. Results: Serum prolidase activity was slightly higher in postmenopausal nonosteoporotic women than in postmenopausal osteoporotic women, but the difference did not reach a statistical significance. Mean values of OSC and IL-6 levels were significantly higher in postmenopausal osteoporotic than in nonosteoporotic women (P < 0.05). There were significant correlations between OSC with IL-6 (r = 0.545, p = 0.01) and urinary DPD (r = -0.513, p = 0.01) in postmenopausal osteoporotic women. Conclusions: Serum prolidase activity in postmenopausal osteoporotic women was not correlated with the bone turnover markers and BMD. Elevated levels of IL-6 in postmenopausal osteoporosis might have an important role in the pathogenesis of postmenopausal osteoporosis.
TOKER, AYSUN; AKSOY, HÜLYA; BÖREKÇİ, BÜNYAMİN; and ÖZKAN, ASUMAN (2007) "Correlations of Serum IL-6 Levels and Prolidase Activity Between Bone Turnover Markers and Bone Mineral Density in Postmenopausal Women With and Without Osteoporosis," Turkish Journal of Medical Sciences: Vol. 37: No. 3, Article 3. Available at: https://journals.tubitak.gov.tr/medical/vol37/iss3/3