Central nervous system (CNS) involvement has been recognized as the second leading cause of death in patients with systemic lupus erythematosus (SLE), although hydrocephalus is seen very rarely. We report a case of communicating hydrocephalus in a 24-year-old woman having previously diagnosed SLE without antiphospholipid antibody syndrome or cerebral venous angiographic abnormality. We propose direct damage-thrombosis of small sized venous structures or immune complex deposition within arachnoid villi, which impair cerebrospinal fluid flow, as a possible, yet unproven, pathophysiologic mechanism for hydrocephalus in SLE.
ALBAYRAK, RAMAZAN; ALBAYRAM, SAİT; SELÇUK, HAKAN; SAİP, SEBAHATTİN; YILMAZ, HALİT; and IŞLAK, CİVAN (2006) "Communicating Hydrocephalus in Systemic Lupus Erythematosus," Turkish Journal of Medical Sciences: Vol. 36: No. 5, Article 11. Available at: https://journals.tubitak.gov.tr/medical/vol36/iss5/11