In Vitro Testing for Genotoxicity of 4-CPA by Sister Chromatid Exchange in Human Lymphocyte Culture

Authors

HÜSEYİN BAĞCI
GÜLSEREN BAĞCI
İBRAHİM AÇIKBAŞ
GÖKSEMİN DEMİR

DOI

-

Abstract

Certain phenoxyacetate derivatives used as plant growth regulators act as plant hormones. 2,4-D dichlorophenoxyacetic acid and 4-chlorophenoxyacetic acid are widely used in vegetable growing, especially tomatoes, in our region. These phenoxyacetic acid compounds are a potential hazard for the environment. There are conflicting results and inconsistent data about these herbicides in the literature. This is the first report of genotoxicity of 4-CPA evaluated by sister chromatid exchange in human lymphocyte culture. No significant change was found in sister chromatid exchange frequency at the tested 4-CPA concentration.

Keywords

4-CPA, Phenoxy herbicides, genotoxicity, sister chromatid exchange, tomato

First Page

75

Last Page

78

Recommended Citation

BAĞCI, HÜSEYİN; BAĞCI, GÜLSEREN; AÇIKBAŞ, İBRAHİM; and DEMİR, GÖKSEMİN (2005) "In Vitro Testing for Genotoxicity of 4-CPA by Sister Chromatid Exchange in Human Lymphocyte Culture," Turkish Journal of Medical Sciences: Vol. 35: No. 2, Article 3. Available at: https://journals.tubitak.gov.tr/medical/vol35/iss2/3