Turkish Journal of Medical Sciences
DOI
-
Abstract
Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.
First Page
71
Last Page
74
Recommended Citation
ATMACA, MUKADDER and FRY, JEFFREY R. (2005) "Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon," Turkish Journal of Medical Sciences: Vol. 35: No. 2, Article 2. Available at: https://journals.tubitak.gov.tr/medical/vol35/iss2/2
