Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.
a-adrenoceptors, glucagon, glutathione, glycogenolysis, hepatocytes receptors
ATMACA, MUKADDER and FRY, JEFFREY R. (2005) "Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon," Turkish Journal of Medical Sciences: Vol. 35: No. 2, Article 2. Available at: https://journals.tubitak.gov.tr/medical/vol35/iss2/2