Turkish Journal of Medical Sciences
DOI
-
Abstract
In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
Keywords
Eclampsia, IUGR, nitric oxide, lipid peroxidation
First Page
89
Last Page
93
Recommended Citation
PAŞAOĞLU, HATİCE; BUKAN, NESLİHAN; BULDUK, GÜLSEN; and ÇELEN, ŞEVKİ (2003) "Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies," Turkish Journal of Medical Sciences: Vol. 33: No. 2, Article 6. Available at: https://journals.tubitak.gov.tr/medical/vol33/iss2/6
