Turkish Journal of Medical Sciences
Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies
In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
Eclampsia, IUGR, nitric oxide, lipid peroxidation
PAŞAOĞLU, HATİCE; BUKAN, NESLİHAN; BULDUK, GÜLSEN; and ÇELEN, ŞEVKİ (2003) "Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies," Turkish Journal of Medical Sciences: Vol. 33: No. 2, Article 6. Available at: https://journals.tubitak.gov.tr/medical/vol33/iss2/6