Turkish Journal of Medical Sciences
Abstract
Lipoprotein oxidation may play a pivotal role in the pathogenesis of atherosclerosis, and vitamin E and b-carotene have been proposed to prevent the development and progression of atherosclerosis. The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B (apo B)-containing lipoproteins and their relation with vitamin E and total carotene levels. The susceptibility of apo B-containing lipoproteins to oxidation, plasma malondialdehyde (MDA), serum vitamin E, total carotene, lipid and lipoprotein levels were studied in 177 patients with coronary artery disease (CAD) and 75 non-CAD subjects. All subjects (n = 252) had undergone coronary catheterization. Student's unpaired t-test, chi-square test and Pearson's correlation test were used for the statistical analyses. CAD patients demonstrated significant decreases in serum vitamin E and total carotene levels and significant increases in low density lipoprotein-cholesterol (LDL-C) and MDA levels. D MDA (oxidizability of apo B-containing lipoproteins) was negatively correlated with vitamin E and inversely correlated with LDL-C, apo B and MDA levels in CAD patients. In conclusion, oxidized forms of apo B-containing lipoproteins may play an important role in the pathogenesis of atherosclerosis, and antioxidant vitamin supplementation may be useful in CAD by improving the oxidative balance.
DOI
-
Keywords
Lipoprotein oxidation, Vitamin E, Total carotene, Coronary artery disease
First Page
379
Last Page
383
Recommended Citation
SERDAR, ZEHRA; SARANDÖL, EMRE; DİRİCAN, MELAHAT; SERDAR, AKIN; YEŞİLBURSA, DİLEK; and TOKULLUGİL, ASUMAN (2002) "Enhanced Susceptibility to in Vitro Oxidation of Apolipoprotein B-Containing Lipoproteins and Antioxidant Status in Patients with Coronary Artery Disease," Turkish Journal of Medical Sciences: Vol. 32: No. 5, Article 4. Available at: https://journals.tubitak.gov.tr/medical/vol32/iss5/4
