Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-\beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-\beta showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-\beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-\beta on both cell lines.
TNF-\beta, 5-FU, ME180, HeLa, Cervical Carcinoma
AKÇA, HAKAN and ÖZEŞ, OSMAN NİDAİ (2002) "Antitumor Effects of TNF-\beta, 5-FU and Their Combinations on Cervical Carcinoma Cell Lines," Turkish Journal of Medical Sciences: Vol. 32: No. 2, Article 7. Available at: https://journals.tubitak.gov.tr/medical/vol32/iss2/7