Turkish Journal of Medical Sciences




From January 1999 through April 2000, 208 Candida strains were obtained from hospitalized patients with nosocomial infection. Most of the species were isolated from urine (77.8%) followed by oropharynx (8.2%), blood stream (6.1%), drain (6.1%), peritoneum (0.9%) and cerebrospinal fluid specimens (0.9%). The distribution of the species obtained was Candida albicans (75.4%), C. glabrata (8.2%), C. tropicalis (4.8%), C. kefyr (3.4%), C. parapsilosis (2.5%), C. lusitaniae (1.9%), C. famata (1.4%), C. krusei (1.4%), and C. guilliermondii (1%). The antifungal susceptibility of the isolates to 5-fluorocytosine (5FCU), amphotericin B (AMP), nystatin (NYS), econazole (ECO), miconazole (MIC) and ketoconazole (KET) was tested by means of the ATB fungus method ((bioMerieux sa Marcy-l'Etoile/France). All the isolates were susceptible to amphotericin B, though a small number of in vitro resistant isolates were observed against nystatin and 5-fluorocytosine (3.4%). The resistance to miconazole, econazole and ketoconazole was higher at 18.8%, 15.8% and 23.6% respectively.


Nosocomial fungal infections, antifungal susceptibility, ATB fungus, Candida.

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