Antifungal activity was determined by the tube dilution method on different extracts of Symphytum sylvaticum Boiss. subsp. sepulcrale (Boiss. & Bal.) Greuter & Burdet var. sepulcrale. The antifungal activity of the isolated compound from the root alkaloid fraction (Echimidine-N-Oxide) was also tested against ten fungal cultures. The activity was found to be mainly due to Echimidine-N-Oxide (ENO). The quantitative determination of ENO was also carried out with capillary gas chromatography in the roots and the aerial parts of the plant.
Symphytum sylvaticum, pyrrolizidine alkaloids, echimidine-N-oxide, antifungal activity, GC analysis
KARTAL, MURAT; KURUCU, SEMRA; and CHOUDARY, MUHAMMAD I. (2001) "Antifungal Activities of Different Extracts and Echimidine-N-oxide from Symphytum sylvaticum Boiss. subsp. sepulcrale (Boiss. & Bal.) Greuter & Burdet var. Sepulcrale," Turkish Journal of Medical Sciences: Vol. 31: No. 6, Article 4. Available at: https://journals.tubitak.gov.tr/medical/vol31/iss6/4