Turkish Journal of Medical Sciences




We investigated whether rCBF values obtained with the SPECT technique are different in schizophrenics with predominantly positive or negative symptoms and assessed the biological underpinnings of psychotic phenomena, which has been done repeatedly in the past, with somewhat varied results. Twenty-nine schizophrenic patients were examined to investigate the relationship between regional cerebral blood flow (rCBF) and psychopathology according to SANS, SAPS and BPRS scores. Using the Tc-99m HMPAO SPECT method at rest, rCBF was assessed in 15 patients with predominantly positive (group I) and 14 with predominantly negative (group II) symptoms. Ten age-matched normal healthy volunteers comprised the control group. We found that the rCBF of group II was prominently decreased in the temporal region compared to that of group I. Basal ganglia rCBF demonstrated a hyperperfusion pattern in medicated vs non-medicated patients (p


schizophrenia, negative/positive symptoms, SPECT.

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