Turkish Journal of Medical Sciences
DOI
-
Abstract
Various relations between apolipoprotein E (apo E) and diabetic nephropathy have been reported. In this study, the question of whether there is any relation between apo E genotypes and microalbuminuria in patients with type-2 diabetes mellitus was examined. Twenty-one male and 25 female patients, with ages the range of 37-62 years (mean 51.7±7.5) with type-2 diabetes mellitus were studied. The apo E genotypes were determined by PCR amplification of the 227 bp region followed by CfoI digestion to release specific band patterns. While 24 patients had microalbuminuria (microalbuminuria group), 22 patients had normoalbuminuria (normoalbuminuria group). The patients with microalbuminuria had suffered from diabetes for a longer period of time (median 13 vs 11 years p
Keywords
Diabetes mellitus, microalbuminuria, apolipoprotein E genotypes
First Page
59
Last Page
64
Recommended Citation
AKARSU, ERSİN; PİRİM, İBRAHİM; ÇAPOĞLU, İLYAS; KAYA, HASAN; AKÇAY, GÜNGÖR; and ÜNÜVAR, NECDET (2001) "A Relation Between the Apolipoprotein E Genotypes and Microalbuminuria in Type 2 Diabetes Mellitus," Turkish Journal of Medical Sciences: Vol. 31: No. 1, Article 9. Available at: https://journals.tubitak.gov.tr/medical/vol31/iss1/9
