Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.
ŞİMŞEK, RAHİME; ŞAFAK, CİHAT; EROL, KEVSER; and VURAL, KAMİL (1999) "S-Aroylmethyl N, N-DisubstitutedDithiocarbamates With Antiparkinson Activity," Turkish Journal of Medical Sciences: Vol. 29: No. 6, Article 6. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss6/6