The Effects of Flutamide on Lipid Profile, InsulinSensitivity, Hirsutism and Gonadotropins inWomen With Polycystic Ovary Syndrome

Authors

MİTHAT BAHCECİ
ALPASLAN TUZCU
MEHMET DURSUN
MELİKSAH ERTEM
VAHİT YÜKSELEN

DOI

-

Abstract

In this study, we evaluated metabolic changes and the effects of flutamide in 22 women with PCOS. Flutamide was administered for a 6-month period in a dose of 750 mg/day. The basal and after treatment body mass index, waist: hip ratio, blood glucose, insulin, lipids, Ferriman-Gallwey scoring (FGS), gonadotropins, testosterone, trasaminazed and glucose: insulin (G:I) ratio were measured. For comparison, ANOVA was used. The sixth month mean FGS was significantly lower than the basal values (18.5±7.4 and 12.5±4.5, P

Keywords

insulin sensitivity, PCOS, flutamide, hirsutism and lipids.

First Page

677

Last Page

682

Recommended Citation

BAHCECİ, MİTHAT; TUZCU, ALPASLAN; DURSUN, MEHMET; ERTEM, MELİKSAH; and YÜKSELEN, VAHİT (1999) "The Effects of Flutamide on Lipid Profile, InsulinSensitivity, Hirsutism and Gonadotropins inWomen With Polycystic Ovary Syndrome," Turkish Journal of Medical Sciences: Vol. 29: No. 6, Article 15. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss6/15