Turkish Journal of Medical Sciences




The protective effect of vitamins E and C on the gastric mucosal barrier in rats irradiated with X-rays was investigated. Thirty-two male Wistar Albino rats were used. The animals were divided into four groups and arranged of follows: the first group (n=8) was the sham group; the second group (n=8) was the control group which was irradiated with X-rays, the third group (n=8) to which vitamin C was administered and the fourth group (n=8) to which vitamin E was given. The animals in the groups except the sham group wereirradiated with 8.9 Gy X-rays. Twenty-four hours later, the animals were sacrificed by cervical disloca-tion. The stomach was removed and opened along the greater curvature. The amounts of mucus and phospholipid, which are the com-ponents of gastric mucosal barrier, were determined by Corne and Baur's method. The amounts in irriadiated rats were found to be lower relative to those in the rats which were not irradiated (p


X-rays, Gastric mucosal barrier, Vitamin E, Vitamin C.

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