Turkish Journal of Medical Sciences




In the present study, we aimed to investigate the effects of dietary salt restriction and loading on extracellular fluid volume (ECFV), blood pressure (BP), heart rate (HR), glomerular filtration rate (GFR) and renal hypertrophy in diabetic rats. Diabetes was induced by injection of streptozotocin (STZ, 65 mg/kg, iv) into male Wistar rats. Four groups were formed: a) the diabetic rats given a standard rat diet (DC), b) the diabetic rats given a high-salt diet (DHS), c) the diabetic rats given a low-salt diet (DLS), d) the nondiabetic rats given a standard rat diet (C). Salt loading and salt restriction were started 7 days after STZ injection and continued for a one-week. Diabetes did not affect ECFV and GFR values significantly, but it led to renal hypertrophy, a reduction in blood pressure (p


Diabetes, blood pressure, extracellular fluid volume, glomerular filtration rate, dietary salt.

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