Turkish Journal of Medical Sciences
Administration of Granulocyte ColonyStimulating Factor (G-CSF) in ExperimentallyInfected Rats
We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats. In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 colony forming units per milliliter of E. coli. Rats were divided into four treatment groups before being inoculaded with E. coli in a random fashion. Therapy was then started with cefotaxime (150 mg/kg intraperitonelally) and either Granulocyte-Colony Stimulation Factor (G-CSF; 30 µg/kg intarperitoneally) or placebo 24 hours after inoculation of E. coli for 3 consective days. Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p
G-CSF, E. coli sepsis, neutropenia.
CEVİT, ÖMER; CEVİT, RUHİYE; KÖYLÜOĞLU, GÖKHAN; İÇAĞASIOĞLU, DİLARA; GÜLTEKİN, ASIM; and TANZER, FATOŞ (1999) "Administration of Granulocyte ColonyStimulating Factor (G-CSF) in ExperimentallyInfected Rats," Turkish Journal of Medical Sciences: Vol. 29: No. 2, Article 6. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss2/6