AgNORs, PCNA and Histologic Activity Index inChronic Liver Disease

Authors

Koray CEYHAN
İlkser AKPOLAT
İbrahim KOBAT
Nazan BOZDOĞAN
Selim EREKUL

DOI

-

Abstract

Chronic hepatitis is a clinical and pathological syndrome, which has several causes and it is characterized by varying degrees of hepatocellular necrosis and inflammation. Several systems have been proposed to evaluate the diagnosis, grading and staging of chronic hepatitis. A histologic activity index (HAI) has been developed which generates a numerical score for liver biopsy specimens obtained from patients with chronic hepatitis. The aim of this study was to evaluate the correlation between HAI and proliferative activity markers, such as PCNA and AgNORs in biopsy specimens obtained from patients with chronic liver disease including chronic hepatitis and cirrhosis. Mean AgNOR counts and HAI were significantly higher in the chronic active hepatitis group than in the chronic persistent hepatitis group (P

Keywords

AgNORs, PCNA, Histologic activity index, chronic liver disease.

First Page

11

Last Page

16

Recommended Citation

CEYHAN, Koray; AKPOLAT, İlkser; KOBAT, İbrahim; BOZDOĞAN, Nazan; and EREKUL, Selim (1999) "AgNORs, PCNA and Histologic Activity Index inChronic Liver Disease," Turkish Journal of Medical Sciences: Vol. 29: No. 1, Article 3. Available at: https://journals.tubitak.gov.tr/medical/vol29/iss1/3