Pulmonary Effects of Dexfenfluramine

Authors

Ferhan CANDAN
Melih KAPTANOĞLU
Reyhan EGİLMEZ
Kasim DOĞAN
Metin AKSOY
Yücel YALMAN
Ebuzer BEKAR
Füsun GÜLTEKİN

DOI

-

Abstract

Dexfenfluramine is a variation of fenfluramine which is used for weight reduction. The aim of the study is to determine the hemodynamic and structural effects of this drug on pulmonary circulation. An experimintal study was carried out with New Zealand Rabbits. A control group (n=30) and an experimintal group (n=20) was constituted. A four-week normal diet for control group and dexfenfluramine plus normala diet for experimental group were applied. Body weights and pulmonary artery pressures of groups were recorded and lungs were collected for pathologic examination. In experimintal group; Dexfenfluramine raised systolic pulmonary artery pressures significantly (p0.05). Weight reduction was obvious (f= 8.522, p

Keywords

Dexfenfluramine, fenfluramine, obesity, appetite depressants, pulmonary hypertension.

First Page

239

Last Page

246

Recommended Citation

CANDAN, Ferhan; KAPTANOĞLU, Melih; EGİLMEZ, Reyhan; DOĞAN, Kasim; AKSOY, Metin; YALMAN, Yücel; BEKAR, Ebuzer; and GÜLTEKİN, Füsun (1998) "Pulmonary Effects of Dexfenfluramine," Turkish Journal of Medical Sciences: Vol. 28: No. 3, Article 4. Available at: https://journals.tubitak.gov.tr/medical/vol28/iss3/4