Alterations of Erythrocyte and Plasma Lipid Peroxides as well as Antioxidant Mechanism in Patients with Type II Diabetes Mellitus (NIDDM)

Authors

Yıldız ATAMER
Yüksel KOÇYİĞİT
Aytaç ATAMER
Nuriye METE
Naime CANORUÇ
Gülten TOPRAK

DOI

-

Abstract

It has been maintained that free oxygen radicals (FOR) that occur in cell have important roles in the ethiopathogenesis of diabet, and that cell damage progressing as a result of their accumulation is responsible for the development of diabetic complications. In recent years, along with free oxygen radicals, antioxidant mechanisms and the substances influencing as free radical cleaner have been investigated in connection with diabet. With this respect, in a total of 30 patients with type II Diabetes Mellitus (NIDDM), 15 with diabetic retinopathy and 15 without diabetic retinopathy, and in 20 healthy subjects, we measured glutathione (GSH), catalase and antiperoxidant superoxide dismutase (SOD) lev-els as well as plasma and eritrosit levels of Malondialdehid (MDA), which is the last product of oxydation of polyunsaturated fatty acids. Erythrocyte and plasma MDA levels of patients with diabetic retinopathy were higher relative to those withouut diabetic retinopathy (P

Keywords

Lipid peroxidation, Superoxide dismutase, catalase, glutathione.

First Page

143

Last Page

148

Recommended Citation

ATAMER, Yıldız; KOÇYİĞİT, Yüksel; ATAMER, Aytaç; METE, Nuriye; CANORUÇ, Naime; and TOPRAK, Gülten (1998) "Alterations of Erythrocyte and Plasma Lipid Peroxides as well as Antioxidant Mechanism in Patients with Type II Diabetes Mellitus (NIDDM)," Turkish Journal of Medical Sciences: Vol. 28: No. 2, Article 7. Available at: https://journals.tubitak.gov.tr/medical/vol28/iss2/7