Turkish Journal of Medical Sciences




The aim of this study is to investigate the frequency of chromosomal abnormalities in men with severe andrological infertility, In 50 men with azoospermia and severe oligoasthenoteratozoospermia (OAT), who referred for our intracytoplasmic sperm injection program, a cytogenetic study has been prospectively carried out. Peripheral blood lymphocytes were cultured for chromosomal analysis and for each proband 30 metaphases were analyzed by GTG banding technique. Major chromosomal abnormalities were detected in 4 of cases (8%). There were 3 sex-chromosome abnormalities, 46XXY in all 3 cases, and one autosomal chromosomal abnormality 46 XY, t (1;7) (P32;Q32). Although the sample size is small, the high frequency of chromosomal abnormalities detected in this preliminary study emphasizes the importance of chromosomal analysis in subfertile men. As prenatal diagnosis is indicated if an infertle man with an abnormal karyotype fathers a child, it is particularly important to know this fact before providing infertility treatment.


Male infertility, chromosomal abnormalities

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