The Dexamethasone Suppression Test in Depressive and Non-Depressive Patients with Fibromyalgia

Authors

Safinaz ATAOĞLU
Ahmet ATAOĞLU
Jale SARAÇ
Ferda ERDOĞAN
Aytekin SIR
Kemal NAS
Mustafa ÖZKAN

DOI

-

Abstract

In most healthy individuals, dexamethasone suppresses adrenal cortisol production. However, in patients with depression, non-suppression frequently occurs. It is considered to be a hyperactivity of the limbichypothalamic pituitary-adrenal (LHPA) axis. To investigate a possible link between fibromyalgia and depression on the basis of response to dexamethasone suppression test (DST), we administered the DST to 20 fibromyalgia patients with depression, 26 nondepressive patients with fibromyalgia and 20 controls. In the fibromyalgia patients with depression. at the mean 16.00 hr, post dexamethasone plasma cortisol level was found significant (LSD: 0.655: p

Keywords

Fibromyalgia, Depression, Dexamethasone suppression test

First Page

447

Last Page

450

Recommended Citation

ATAOĞLU, Safinaz; ATAOĞLU, Ahmet; SARAÇ, Jale; ERDOĞAN, Ferda; SIR, Aytekin; NAS, Kemal; and ÖZKAN, Mustafa (1997) "The Dexamethasone Suppression Test in Depressive and Non-Depressive Patients with Fibromyalgia," Turkish Journal of Medical Sciences: Vol. 27: No. 5, Article 11. Available at: https://journals.tubitak.gov.tr/medical/vol27/iss5/11