Turkish Journal of Medical Sciences

The Effect of Hyperlipidemia on ERP Spectral Components




The purpose of this study was to investigate cognitive changes in hyperlipidemic patients by means of spectral parameters of event-related brain potentials (ERPs). ERPs of 20 hyperlipidemic patients and age-matched healthy controls were elicited using infrequent and frequent stimuli in the form of red and green lights, respectively. The inferequent stimulus had a 15% probability. ERPs were recorded under two different experimental conditions: one where the infrequent stimulus was counted (Test 1) and one where it was uncounted (Test 2). Amplitude spectra of ERPs were computed with the transient response-frequency characteristics (TRFC) method. Their maxima were observed in the frequency bands 1-2, 3-4, 5-7, 8-12, 13-20 and 20.5-32 Hz.The amplitude means (decibel) of the 1-2 and 3-4 frequency bands were decreased in Test 2 in comparison with Test 1 in the control group, but no amplitude differences were found between Test 1 and Test 2 in the hyperlipidemic group.


Event-related potentials, decision-making, visual, spectral components, hyperlipidemia

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