Turkish Journal of Medical Sciences

0ndansetron: The Prevention of Nausea and Vomiting in Gynecologic 0perations




The efficacy and side effects of ondansetron, a selective 5 hydroxytryptamine subtype lll (5-HT 3) receptor antagonist, in prevention of postoperative nausea and vomiting in gynecologic intraabdominal surgery and laparoscopy were studied. 0ne hundred forty cases were included in the study. 8 mg ondansetron was administered intravenously in 2-5 minutes immediately before induction of anesthesia in 54 laparotomy and 20 laparoscopy cases a total of 74. Forty laparotomy and 26 laparoscopic surgery cases, a total of 66, were used as a control group. Nausea scoring in the first 24 hours, episodes of vomiting and the need for additional antiemetics were recorded. Mean number of vomiting episodes was higher in both the laparotomy and laparoscopy groups of the control group when compared with the ondansetron group (p


0ndansetron, postoperative emesis.

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