Turkish Journal of Medical Sciences
Treatment of Endometriosis with Gn-Rh Agonist Triptorelin: A Multicenter Study
Abstract
A multicenter trial was carried out to evaluate the safety and efficacy of long acting preparation of Triptorelin-3.75 mg. (Decapeptlyl-Ferring/Erkim-Sweden) for the treatment of endometriosis. A total of 110 patients from 13 institutions with stage ll or higher endometriosis scores were included in the study; 105 of them completed the therapy. Patients underwent a 6-month course of monthly intramuscular injections during which changes in endometriosis symptoms, in biochemical, hematological, hormonal parameters and bone metabolism were evaluated. During the initial laparoscopy peritoneal implants were untouched; whereas of the 46 endometriomas encountered, they were either untouched (n: 13) or a surgical procedure [drainage(n: 23) fulguration (n: 3) cystectomy (n: 7)] was performed. At the end of the treatment, a second-look laparoscopy was performed (n: 93) to determine the efficacy of treatment on endometriotic implants. Initially 64% of patients complained of pelvic pain which dropped to 32% at the end of the treatment. Total AFS score, implants score, and implants score excluding endometriomas dropped significanly (p
DOI
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Keywords
Endometriosis, gonadotropin releasing hormone agonist, Triptorelin, ovarian endometrioma, laparoscopy.
First Page
261
Last Page
266
Recommended Citation
GÖKMEN, 0ya and UĞUR, Mustafa (1996) "Treatment of Endometriosis with Gn-Rh Agonist Triptorelin: A Multicenter Study," Turkish Journal of Medical Sciences: Vol. 26: No. 3, Article 9. Available at: https://journals.tubitak.gov.tr/medical/vol26/iss3/9