Turkish Journal of Medical Sciences

Immunophenotyping in Acute Leukemias




The incidence and clinical implication of unusual patterns of expression of leukocyte differentiation antigens in acute leukemia were assessed on 54 newly diagnosis pediatric and adult cases undergoing Immunophenotyping with a panel of monoclonal antibodies. The diagnosis was based on FAB morphology and cytohemistry by the pediatric and adult hematologist. 0f the 37 cases in childhood, 27 (70.3 %) had acute lymphoblastic leukemia (ALL) and of the 17 adults, 5 (29.4 %) had ALL. 0ne patients in childhood (3.7 %) and an adult (20 %) with ALL expressed myeloid surface antigens. T-lineage markers as well as CD10 antigen. Ten cases (27 %) in childhood showed expression of CD13 and CD 33. Furthermore, 4 of them (40 %) expressed CD14 antigen in addition to CD13 and CD 33 antigens. Twelve adults (70 %) expressed either CD13 or CD33 antigens and 4 cases (33.3 %) with acute myelomonocytic leukemia (AMML) showed expression of CD14 antigen. T-lineage markers were expressed in a child (10 %) and in 3 adults (25 %) with acute myeloblastic leukemia (AML).


Immunophenotyping, Acute leukemia

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