Sensitive electrochemical sensor for simultaneous determination of epinephrine and norepinephrine by SiO2NP@MWCNT-COOH nanoparticle-modified SPCEs​

Authors

• MERVE YILMAZ ÇILÇARFollow
• MELİKE BİLGİ KAMAÇFollow
• AYŞENUR YILMAZ KABACAFollow
• ŞAHİN TOPARLIFollow
• FARUK TERZİOĞLUFollow
• EMİR ATEŞFollow

Abstract

Epinephrine (EP) and norepinephrine (NEP), both neurotransmitters, are two important biomolecules that play critical roles in the body, from the central nervous system to metabolic processes. They are also important biomarkers for clinical diagnosis and monitoring. In this study, a novel, fast, practical, and high-performance electrochemical sensor based on a SiO2NP@MWCNT-COOH nanocomposite was developed for the simultaneous determination of EP and NEP. The nanocomposite was modified onto the surface of screen-printed electrodes (SPCEs) and its characterization was performed (SEM-EDX, XRD, FTIR, CV, DPV, and EIS). The individual and simultaneous determinations of EP and NEP were performed using square-wave voltammetry, yielding a wide linear range and low detection limits. The developed sensor successfully measured EP-NEP levels simultaneously in commercial human blood serum samples with high recovery rates. Analysis of selectivity and shelf-life demonstrated that the proposed sensor exhibited high selectivity and stability. While further validation with real clinical samples is required, this nanocomposite-based electrochemical sensor provides promising proof-of-concept for potential future use in rapid and reliable point-of-care applications.

Author ORCID Identifier

MERVE YILMAZ ÇILÇAR: 0000-0003-3690-2455

MELİKE BİLGİ KAMAÇ: 0000-0002-3381-7522

AYŞENUR YILMAZ KABACA: 0000-0002-1189-405X

ŞAHİN TOPARLI: 0009-0008-5740-4053

FARUK TERZİOĞLU: 0009-0005-0904-5170

EMİR ATEŞ: 0009-0006-4258-6101

DOI

10.55730/1300-0527.3903

Keywords

Simultaneous detection, epinephrine, norepinephrine, silicon oxide nanoparticles, multiwalled carbon nanotubes, screen-printed carbon electrode

First Page

369

Last Page

385

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

YILMAZ ÇILÇAR, M, BİLGİ KAMAÇ, M, YILMAZ KABACA, A, TOPARLI, Ş, TERZİOĞLU, F, & ATEŞ, E (2026). Sensitive electrochemical sensor for simultaneous determination of epinephrine and norepinephrine by SiO2NP@MWCNT-COOH nanoparticle-modified SPCEs​. Turkish Journal of Chemistry 50 (4): 369-385. https://doi.org/10.55730/1300-0527.3903