Turkish Journal of Chemistry
Abstract
Lanthanum metal complexes were synthesized using a classical condensation method by reacting lanthanum nitrate salts with a bidentate ligand in a 1:2:1 molar ratio (M:L:L). The formation and structure of the resulting complexes were confirmed through a combination of analytical techniques, including Fourier transformation infrared spectroscopy, thermal gravimetric analysis, X-ray diffraction, elemental microanalysis, and scanning electron microscopy. The lanthanum complexes synthesized exhibited strong in vitro antimicrobial activity. Antibacterial screening showed inhibition zones of 18–26 mm against Staphylococcus aureus and Escherichia coli, surpassing those of the reference drug ciprofloxacin (16–20 mm). Antifungal studies demonstrated inhibition zones of 15–23 mm against Candida albicans and Aspergillus niger. The MIC values ranged from 25 to 50 μg/mL, indicating high potency. Additionally, moderate antimalarial activity was observed against Plasmodium falciparum (IC50 = 12.4 μM). These findings confirm that lanthanum complexes possess potent antibacterial and antifungal properties, highlighting their promise as potential candidates for novel antimicrobial and antimalarial drug development.
Author ORCID Identifier
SHANTANU KADAM: 0009-0004-4327-2441
BHUSHAN DHALE: 0000-0001-7029-2430
BAPU YAMGAR: 0009-0007-3996-7955
SWAMINATH BHATTAR: 0009-0008-5854-7566
DOI
10.55730/1300-0527.3778
Keywords
Lanthanum metal complexes, analytical techniques, elemental microanalysis, thermogravimetric analysis, antifungal studies
First Page
38
Last Page
48
Publisher
The Scientific and Technological Research Council of Türkiye (TÜBİTAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
KADAM, S, DHALE, B, YAMGAR, B, & BHATTAR, S (2026). Investigating the structure and bioactivity of lanthanum coordination compounds. Turkish Journal of Chemistry 50 (1): 38-48. https://doi.org/10.55730/1300-0527.3778
