Turkish Journal of Chemistry
Abstract
Novel coumarin–triazole–coumarin dyads were synthesized and characterized, and their α-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC50 value of 38.98 ± 0.77 μM. The IC50 values for 4d and 4a were 93.55 ± 1.70 μM and 95.04 ± 3.55 μM, respectively. The Lineweaver–Burk plot showed that 4e inhibited α-glycosidase in a mixed type. In addition, the Ki value obtained from the Dixon plot was 19.95 ± 0.15 μM for α-glycosidase.
Author ORCID Identifier
ERSİN ŞİRİN: 0000-0003-2034-0734
ESRA SEVİMLİ: 0000-0002-7935-3954
GÖKÇE SEYHAN: 0000-0002-8553-9093
BURAK BARUT: 0000-0002-7441-8771
YUNUS KAYA: 0000-0001-7228-2340
BAYBARS KÖKSOY: 0000-0001-7939-5380
DOI
10.55730/1300-0527.3770
Keywords
Coumarin, triazole, enzyme inhibition, α-glycosidase
First Page
780
Last Page
792
Publisher
The Scientific and Technological Research Council of Türkiye (TÜBİTAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
ŞİRİN, E, SEVİMLİ, E, SEYHAN, G, BARUT, B, KAYA, Y, & KÖKSOY, B (2025). α-Glycosidase activity of novel coumarin–triazole–coumarin dyads. Turkish Journal of Chemistry 49 (6): 780-792. https://doi.org/10.55730/1300-0527.3770
