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Turkish Journal of Chemistry

Abstract

Several biomarkers have been developed to track the development of ovarian cancer and identify the illness at an early stage. A promising development for ovarian cancer is using cancer antigen 125 (CA125). The objective of this work is to identify the CA125 marker by utilizing an indium tin oxide polyethylene electrode. The advantage of the designed biosensor is that it is very cheap, disposable, practical, and easy to use. The necessary parameters for the developed biosensor have been optimized in detail. Repeatability, reproducibility, regeneration, storage, and selectivity studies have been completed to characterize the proposed biosensor. Electrochemical impedance spectroscopy and cyclic voltammetry techniques were used for all experimental investigations of the proposed biosensor. The immunosensor offers a large linear detection range (0.01–100 pg/mL). Moreover, this developed sensor has a 0.018 pg/mL limit of detection and a 0.06 pg/mL limit of quantification. The high accuracy of this biosensor was observed in five commercial human serums.

Author ORCID Identifier

MELTEM AFŞAR: 0000-0002-4551-756X

BERFİN VURAL: 0000-0003-2752-9708

MELİKE BİLGİ KAMAÇ: 0000-0002-3381-7522

MUSTAFA KEMAL SEZGİNTÜRK: 0000-0003-3042-1087

DOI

10.55730/1300-0527.3748

Keywords

CA125, biosensor, ovarian cancer, p-benzoquinone

First Page

511

Last Page

519

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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