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Turkish Journal of Chemistry

Abstract

In this research, a fast and simple spectrophotometric method is presented for mitoxantrone determination in various aqueous samples. It utilizes preconcentration by salt saturated pipette-tip micro solid phase extraction with a selective molecularly imprinted polymer adsorbent packed in a micropipette tip. Prior to sample loading, they were saturated with a mixture of NaCl, Mg (NO3)2.6H2O and KNO3 salts, enhancing extraction efficiency by 27.5% compared to salt-free conditions. Key microextraction parameters (amount of molecularly imprinted polymer, sample pH, eluent type/volume, and adsorption/desorption cycles) were optimized using response surface methodology and one-variable-at-a-time methods. The method achieves a low detection limit (0.2 μg L⁻¹) and a wide linear range (1–1000 μg L⁻¹). An enrichment factor of 49 is obtained with excellent accuracy (relative standard deviation <4.4%). The method was validated by comparing it to a standard high performance liquid chromatography protocol, as well as spiking real samples in three concentration levels. The method successfully detected low levels of mitoxantrone in various water samples.

Author ORCID Identifier

SAYYED HOSSEINMINA HASHEMIESMAILIUN: 0000-0002-1351-4292

MASSOUD KAYKHAII: 0000-0003-2890-9286

AHMAD KEIKHA: 0000-0001-9053-6236

DOI

10.55730/1300-0527.3728

Keywords

Mitoxantrane, salt saturated pipette-tip micro solid phase extraction, molecularly imprinted polymer, response surface methodology, environmental water analysis

First Page

267

Last Page

278

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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