Vilsmeier–Haack Complex Formation by Fe₃O₄@SiO₂@CS@POCl_2–x/DMF: An Efficient Catalyst for Conversion of Epoxides to β-Bromoformates

Authors

FARZANEH EBRAHIMZADEHFollow

Abstract

The in situ generation of the Vilsmeier–Haack complex was studied by combining Fe₃O₄@SiO₂@CS@POCl_2–x with N,N-dimethylformamide (DMF), demonstrating remarkable efficiency and regioselectivity in transforming epoxides into β-bromoformates. The reported yields were notably high and were achieved under mild reaction conditions. Interestingly, the removal of DMF led to the synthesis of vic-dihalide compounds. The product of this transformation depended on the specific details of how the experiment was done, highlighting how sensitive the process is to different ways of conducting the experiment. The use of a magnetic core-shell catalyst, Fe₃O₄@SiO₂@CS@POCl_2–x, facilitates a straightforward work-up procedure, simplifying the isolation of the desired products. Furthermore, the reactions were conducted under clean and neutral conditions, contributing to their environmentally friendly nature.

Author ORCID Identifier

FARZANEH EBRAHIMZADEH: 0000-0001-5825-7288

DOI

10.55730/1300-0527.3717

Keywords

Magnetic nanocatalyst, Vilsmeier-Haack complex, β-bromoformates epoxide, bromide, core-shell structure

First Page

133

Last Page

142

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

EBRAHIMZADEH, F (2025). Vilsmeier–Haack Complex Formation by Fe₃O₄@SiO₂@CS@POCl_2–x/DMF: An Efficient Catalyst for Conversion of Epoxides to β-Bromoformates. Turkish Journal of Chemistry 49 (2): 133-142. https://doi.org/10.55730/1300-0527.3717