Nonadhesive membranes: preparation and characterization of modified PHBHX membranes

Authors

FUNDA ALKANFollow
MURAT DEMİRBİLEKFollow
OKTAY AYDINFollow
BERRAK GÜMÜŞKAYA ÖCALFollow
NELİSA LAÇİN TÜRKOĞLUFollow
MUSTAFA TÜRKFollow
MEHMET ALİ ONURFollow

Abstract

After abdominal surgery, there is a possibility of adhesions between the abdominal organs and the abdominal wall. Theadhesions can lead to problems such as chronic pain, intestinal blockage, and infertility. To prevent adhesion, antiadhesion patchescan be used. In this study, poly hydroxybutyrate-co-hexanoate membranes were fabricated as antiadhesion patches and modified witheither fatty acids or polyethylene glycol. The homogeneity and protein absorption of the membranes were assessed. The effects onblood coagulation factors were determined and the adhesion-proliferation properties of human fibroblast cells on the membranes weredetermined. The results show that myristic acid slightly increases surface free energy (40.7 ± 4.2 mN/m), decreases polar interaction (6.7± 0.7%), and has no effect on cell adhesion or proliferation at low concentrations, but does at high concentrations. Oleic acid slightlyincreases surface free energy (45.91 ± 4.8 mN/m), does not affect polar interaction (11.4 ± 0.9%), and increases cell proliferation at lowconcentrations. Both polyethylene glycol 400 and polyethylene glycol 8000 decrease cell adhesion and proliferation and do not changethe surface free energy of membranes (39.6 ± 2.6 mN/m and 37.8 ± 1.8 mN/m, respectively), but decrease polar interaction (6.6 ± 0.3%and 5.1 ± 0.2%, respectively). In conclusion, the modified membrane is a good candidate for an antiadhesion patch for abdominalsurgery.

Author ORCID Identifier

FUNDA ALKAN: 0000-0003-1933-322X

MURAT DEMİRBİLEK: 0000-0001-6990-5607

OKTAY AYDIN: 0000-0001-5728-0128

BERRAK GÜMÜŞKAYA ÖCAL: 0000-0003-0599-8968

NELİSA LAÇİN TÜRKOĞLU: 0000-0001-9118-5183

MUSTAFA TÜRK: 0000-0001-8202-090X

MEHMET ONUR: 0000-0002-3630-7982

DOI

10.55730/1300-0527.3710

Keywords

PHBHX, antiadhesive membrane, fatty acids, polyethylene glycol

First Page

54

Last Page

67

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

ALKAN, FUNDA; DEMİRBİLEK, MURAT; AYDIN, OKTAY; GÜMÜŞKAYA ÖCAL, BERRAK; LAÇİN TÜRKOĞLU, NELİSA; TÜRK, MUSTAFA; and ONUR, MEHMET ALİ (2025) "Nonadhesive membranes: preparation and characterization of modified PHBHX membranes," Turkish Journal of Chemistry: Vol. 49: No. 1, Article 5. https://doi.org/10.55730/1300-0527.3710
Available at: https://journals.tubitak.gov.tr/chem/vol49/iss1/5